In-depth research and analyze how the pandemic changed the way for-profit art businesses, especially art galleries (mega galleries like David Zwirner, GAGOSIAN, Pace galley etc. and small galleries); auction houses; and art fairs, operates in the past year and in the future, as well as long-term. In the paper, discuss some of the new ways/ideas for-profit art business has come up with to adapt to the shutdown of the whole world and if these ways are successful. In addition, how are they going to operate in the future? In addition, How is NFT stands in this situation, has it changed and interrupted with other art businesses?